Publications
Publications
Explore scientific publications and research contributions from the Drug Delivery innovation Center.
Explore scientific publications and research contributions from the Drug Delivery innovation Center.
Entries are grouped by year. Publication titles, authors and types are reproduced from the INVITE archive. Where the source provides no link, this is indicated explicitly.
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2025
Publication
Authors
Type
Link
Co-sorption of volatile components in polymer-based pharmaceutical formulations
Co-sorption of volatile components in polymer-based pharmaceutical formulations
J. Kerkhoff, D. Bormann, G. Sadowski
J. Kerkhoff, D. Bormann, G. Sadowski
research paper
research paper
Drying Kinetics of Polymer-baased Pharmaceutical Formulations
Drying Kinetics of Polymer-baased Pharmaceutical Formulations
J. Kerkhoff, N. Opitz, D. Bormann, G. Sadowski
J. Kerkhoff, N. Opitz, D. Bormann, G. Sadowski
research paper
research paper
Water-assisted drying of PVPVA-based amorphous solid dispersions
Water-assisted drying of PVPVA-based amorphous solid dispersions
J. Kerkhoff, N. Opitz, L. Peters, D. Bormann, G. Sadowski
J. Kerkhoff, N. Opitz, L. Peters, D. Bormann, G. Sadowski
research paper
research paper
2024
Publication
Authors
Type
Link
Measuring and Modeling of Melt Viscosity for Drug Polymer Mixtures
Measuring and Modeling of Melt Viscosity for Drug Polymer Mixtures
V. Kimmel, E. Ercolin, R. Zimmer, M. Yörük, J. Winck, M. Thommes
V. Kimmel, E. Ercolin, R. Zimmer, M. Yörük, J. Winck, M. Thommes
research paper
research paper
Modeling non-Newtonian polymer flow behavior in pharmaceutical twin-screw extrusion processes
Modeling non-Newtonian polymer flow behavior in pharmaceutical twin-screw extrusion processes
V. Kimmel, J. Winck, M. Thommes
V. Kimmel, J. Winck, M. Thommes
poster presentation
poster presentation
–
Controlling quality and kinetics of ASD drying processes
Controlling quality and kinetics of ASD drying processes
J. Kerkhoff, D. Borrmann, G. Sadowski
J. Kerkhoff, D. Borrmann, G. Sadowski
poster presentation
poster presentation
–
Evaluation of mannitol / sodium starch glycolate based inks for semi-solid extrusion of inks
Evaluation of mannitol / sodium starch glycolate based inks for semi-solid extrusion of inks
C. Mentrup, T. Auel, J. Breitkreutz, A. Seidlitz
C. Mentrup, T. Auel, J. Breitkreutz, A. Seidlitz
poster presentation
poster presentation
–
Characterization of the Design Space in a Pharmaceutical Packaging Line Regarding Blister Integrity
Characterization of the Design Space in a Pharmaceutical Packaging Line Regarding Blister Integrity
A. Márton, J. Bartsch, R. Heumann, W. Hoheisel, M. Markus, M.Thommes
A. Márton, J. Bartsch, R. Heumann, W. Hoheisel, M. Markus, M.Thommes
poster presentation
poster presentation
–
Distributive Mischeigenschaften von Schneckenelementen zur Modellierung pharmazeutischer Extrusionsprozesse
Distributive Mischeigenschaften von Schneckenelementen zur Modellierung pharmazeutischer Extrusionsprozesse
V. Kimmel, J. Winck, M. Thommes
V. Kimmel, J. Winck, M. Thommes
oral presentation
oral presentation
–
2023
Publication
Authors
Type
Link
Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Winck J, Gottschalk T, Thommes M.
Winck J, Gottschalk T, Thommes M.
research paper
research paper
Customizable 3D Printed Implants Containing Triamcinolone Acetonide: Development, Analysis, Modification, and Modeling of Drug Release
Customizable 3D Printed Implants Containing Triamcinolone Acetonide: Development, Analysis, Modification, and Modeling of Drug Release
H.Ponsar, J.Quodbach
H.Ponsar, J.Quodbach
research paper
research paper
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions
F. Wolbert, C.Luebbert, G.Sadowski
F. Wolbert, C.Luebbert, G.Sadowski
research paper
research paper
2022
Publication
Authors
Type
Link
Tracking raw material flow through a continuous direct compression line Part I of II: Residence time distribution modeling and sensitivity analysis enabling increased process yield
Tracking raw material flow through a continuous direct compression line Part I of II: Residence time distribution modeling and sensitivity analysis enabling increased process yield
M. Peterwitz, J. Jodwirschat, R. Loll, G. Schembecker
M. Peterwitz, J. Jodwirschat, R. Loll, G. Schembecker
research paper
research paper
Tracking raw material flow through a continuous direct compression line. Part II of II: Predicting dynamic changes in quality attributes of tablets due to disturbances in raw material properties using an independent residence time distribution model
Tracking raw material flow through a continuous direct compression line. Part II of II: Predicting dynamic changes in quality attributes of tablets due to disturbances in raw material properties using an independent residence time distribution model
M. Peterwitz, S. Buchgeister, R. Meier, G. Schembecker
M. Peterwitz, S. Buchgeister, R. Meier, G. Schembecker
research paper
research paper
Factors Influencing the Crystallization-Onset Time of Metastable ASDs
Factors Influencing the Crystallization-Onset Time of Metastable ASDs
F. Wolbert, I.-K Fahrig, T. Gottschalk, C. Luebbert, M. Thommes and G. Sadowski
F. Wolbert, I.-K Fahrig, T. Gottschalk, C. Luebbert, M. Thommes and G. Sadowski
research paper
research paper
Influence of process temperature and residence time on the manufacturing of amorphous solid dispersions in hot melt extrusion
Influence of process temperature and residence time on the manufacturing of amorphous solid dispersions in hot melt extrusion
T. Gottschalk, B. Grönniger ,E. Ludwig, F. Wolbert, T. Feuerbach, G. Sadowski and M. Thommes
T. Gottschalk, B. Grönniger ,E. Ludwig, F. Wolbert, T. Feuerbach, G. Sadowski and M. Thommes
research paper
research paper
Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes
Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes
M. Peterwitz, S. Gerling, G. Schembecker
M. Peterwitz, S. Gerling, G. Schembecker
research paper
research paper
Simplified choice of suitable excipients within biologics formulation design using protein-protein interaction- and water activity-maps
Simplified choice of suitable excipients within biologics formulation design using protein-protein interaction- and water activity-maps
T. Stolzke, C. Brandenbusch
T. Stolzke, C. Brandenbusch
research paper
research paper
Development of sustained-release drug-loaded intravesical inserts via semi-solid micro-extrusion 3D-printing for bladder targeting
Development of sustained-release drug-loaded intravesical inserts via semi-solid micro-extrusion 3D-printing for bladder targeting
J. Rahman-Yildir, B. Fischera, J. Breitkreutz
J. Rahman-Yildir, B. Fischera, J. Breitkreutz
research paper
research paper
Comparative dissolution studies of 3D-printed inserts in a novel biopharmaceutical bladder model
Comparative dissolution studies of 3D-printed inserts in a novel biopharmaceutical bladder model
J. Rahman-Yildir, R. Wiedey , J. Breitkreutz
J. Rahman-Yildir, R. Wiedey , J. Breitkreutz
research paper
research paper
Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
T. Gottschalk, C. Özbay, T. Feuerbach, M. Thommes
T. Gottschalk, C. Özbay, T. Feuerbach, M. Thommes
research paper
research paper
Hydroxylpropyl-β-cyclodextrin as Potential Excipient to Prevent Stress-Induced Aggregation in Liquid Protein Formulations
Hydroxylpropyl-β-cyclodextrin as Potential Excipient to Prevent Stress-Induced Aggregation in Liquid Protein Formulations
T. Stolzke, F. Krieg, T. Peng, H. Zhang, O. Häusler, C. Brandenbusch
T. Stolzke, F. Krieg, T. Peng, H. Zhang, O. Häusler, C. Brandenbusch
research paper
research paper
The Shelf Life of ASDs: 1. Measuring the Crystallization Kinetics at Humid Conditions
The Shelf Life of ASDs: 1. Measuring the Crystallization Kinetics at Humid Conditions
F. Wolbert, K. Nikoleit, M. Steinbrink, C. Luebbert, G. Sadowski
F. Wolbert, K. Nikoleit, M. Steinbrink, C. Luebbert, G. Sadowski
research paper
research paper
2021
Publication
Authors
Type
Link
Versatility on demand - the case for semi-solid micro-extrusion in pharmaceutics
Versatility on demand - the case for semi-solid micro-extrusion in pharmaceutics
J. Rahman, J. Quodbach
J. Rahman, J. Quodbach
research paper
research paper
Evaluating the potential for optimization of axial back mixing in continuous pharmaceutical manufacturing
Evaluating the potential for optimization of axial back mixing in continuous pharmaceutical manufacturing
M. Peterwitz, G. Schembecker
M. Peterwitz, G. Schembecker
research paper
research paper
Evaluation of Binders in Twin-Screw Wet Granulation
Evaluation of Binders in Twin-Screw Wet Granulation
C. Köster, S. Pohl, P. Kleinebudde
C. Köster, S. Pohl, P. Kleinebudde
research paper
research paper
2020
Publication
Authors
Type
Link
Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms
Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms
H. Ponsar, R. Wiedey, J. Quodbach
H. Ponsar, R. Wiedey, J. Quodbach
research paper
research paper
Development and Evaluation of an In-line and On-line Monitoring System for Granule Size Distributions in Continuous Roll Compaction/Dry Granulation Based on Laser Diffraction
Development and Evaluation of an In-line and On-line Monitoring System for Granule Size Distributions in Continuous Roll Compaction/Dry Granulation Based on Laser Diffraction
A. Wilms, R. Meier, P. Kleinebudde
A. Wilms, R. Meier, P. Kleinebudde
research paper
research paper
A review of regime maps for granulation
A review of regime maps for granulation
S. Pohl, P. Kleinebudde
S. Pohl, P. Kleinebudde
research paper
research paper
Viscosity of ASDs at humid conditions
Viscosity of ASDs at humid conditions
F. Wolbert, J. Stecker, C. Luebbert, G. Sadowski
F. Wolbert, J. Stecker, C. Luebbert, G. Sadowski
research paper
research paper
Optimization of residence time distribution in RCDG and an assessment of its applicability in continuous manufacturing
Optimization of residence time distribution in RCDG and an assessment of its applicability in continuous manufacturing
A. Wilms, P. Kleinebudde
A. Wilms, P. Kleinebudde
research paper
research paper
Towards better understanding of the influence of process parameters in roll compaction/dry granulation on throughput, ribbon microhardness and granule failure load
Towards better understanding of the influence of process parameters in roll compaction/dry granulation on throughput, ribbon microhardness and granule failure load
A. Wilms, P. Kleinebudde
A. Wilms, P. Kleinebudde
research paper
research paper
Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled Impeller Speed of the Granulation Unit, Compaction Force and Gap Width
Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled Impeller Speed of the Granulation Unit, Compaction Force and Gap Width
A. Wilms, A. Teske, R. Meier, R. Wiedey & P. Kleinebudde
A. Wilms, A. Teske, R. Meier, R. Wiedey & P. Kleinebudde
research paper
research paper
3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing
3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing
I. El Aita, J. Rahman, J. Breitkreutz, P. Kleinebudde
I. El Aita, J. Rahman, J. Breitkreutz, P. Kleinebudde
research paper
research paper
On-line measurement of granule size distribution by dynamic image analysis in a continuous manufacturing line
On-line measurement of granule size distribution by dynamic image analysis in a continuous manufacturing line
A.Wilms, P.Kleinebudde
A.Wilms, P.Kleinebudde
poster presentation
poster presentation
On-line measurement of granule size distribution by laser diffraction in a continuous manufacturing line
On-line measurement of granule size distribution by laser diffraction in a continuous manufacturing line
A.Wilms, P.Kleinebudde
A.Wilms, P.Kleinebudde
poster presentation
poster presentation
Excipient selection for HCPF-Design
Excipient selection for HCPF-Design
T. Stolzke, C. Brandenbusch
T. Stolzke, C. Brandenbusch
poster presentation
poster presentation
–
Optimization procedure for hot melt extrusion as a continuous manufacturing technique for amorphous solid dispersions
Optimization procedure for hot melt extrusion as a continuous manufacturing technique for amorphous solid dispersions
T. Gottschalk, C. Özbay, T. Feuerbach, M. Thommes
T. Gottschalk, C. Özbay, T. Feuerbach, M. Thommes
poster presentation
poster presentation
2019
Publication
Authors
Type
Link
Combination of a rotating tube sample divider and dynamic image analysis for continuous on-line determination of granule size distribution
Combination of a rotating tube sample divider and dynamic image analysis for continuous on-line determination of granule size distribution
A.Wilms, K.Knop, P.Kleinebudde
A.Wilms, K.Knop, P.Kleinebudde
research paper
research paper
Excipient Choice for High Concentration Protein Formulations based on Molecular Interactions
Excipient Choice for High Concentration Protein Formulations based on Molecular Interactions
T. Stolzke, C. Brandenbusch
T. Stolzke, C. Brandenbusch
poster presentation
poster presentation
–
Thermodynamische und kinetische Stabilität von amorphen pharmazeutischen Formulierungen
Thermodynamische und kinetische Stabilität von amorphen pharmazeutischen Formulierungen
F. Wolbert, C. Lübbert, G. Sadowski
F. Wolbert, C. Lübbert, G. Sadowski
poster presentation
poster presentation
–
Untersuchung des Einflusses von Aminosäuren auf die molekularen Wechselwirkungen in hochkonzentrierten Proteinformulierungen
Untersuchung des Einflusses von Aminosäuren auf die molekularen Wechselwirkungen in hochkonzentrierten Proteinformulierungen
T. Stolzke, C. Brandenbusch
T. Stolzke, C. Brandenbusch
poster presentation
poster presentation
–
In-line detercmination of granule size distribution during continuous roll compaction/dry granulation by laser diffraction
In-line detercmination of granule size distribution during continuous roll compaction/dry granulation by laser diffraction
A. Wilms, K.Knop, P. Kleinebudde
A. Wilms, K.Knop, P. Kleinebudde
poster presentation
poster presentation
Development of Novel Intravesical Inserts via 3D-Printing
Development of Novel Intravesical Inserts via 3D-Printing
J. Rahman, J. Breitkreutz
J. Rahman, J. Breitkreutz
poster presentation
poster presentation
Use of mixer torque rheometry to predict optimal L/S ratio for twin-screw granulation
Use of mixer torque rheometry to predict optimal L/S ratio for twin-screw granulation
S. Pohl, P. Kleinebudde
S. Pohl, P. Kleinebudde
poster presentation
poster presentation
Development of Non-biodegradable Filaments for 3D-printed Implant Inserts
Development of Non-biodegradable Filaments for 3D-printed Implant Inserts
H. Ponsar, J. Quodbach
H. Ponsar, J. Quodbach
poster presentation
poster presentation
Particle size distribution in the product stream after roll compaction/dry granulation
Particle size distribution in the product stream after roll compaction/dry granulation
A. Wilms, K.Knop, P. Kleinebudde
A. Wilms, K.Knop, P. Kleinebudde
poster presentation
poster presentation
Development and Application of an Optimization Procedure for an Operating Point in Hot Melt Extrusion
Development and Application of an Optimization Procedure for an Operating Point in Hot Melt Extrusion
T. Gottschalk, J. Wesholowski1, C. Mühlenfeld3, M. Thommes
T. Gottschalk, J. Wesholowski1, C. Mühlenfeld3, M. Thommes
poster presentation
poster presentation
Repräsentative Probenteilung für die Walzenkompaktierung
Repräsentative Probenteilung für die Walzenkompaktierung
A. Wilms, P. Kleinebudde
A. Wilms, P. Kleinebudde
poster presentation
poster presentation
Repräsentative Probenteilung für die Walzenkompaktierung
Repräsentative Probenteilung für die Walzenkompaktierung
A. Wilms, P. Kleinebudde
A. Wilms, P. Kleinebudde
poster presentation
poster presentation
–
Continuous Determination of granule size distribution using dynamic image analysis
Continuous Determination of granule size distribution using dynamic image analysis
A. Wilms, K.Knop, P. Kleinebudde
A. Wilms, K.Knop, P. Kleinebudde
oral presentation
oral presentation
–
2018
Publication
Authors
Type
Link
How relevant is ribbon homogeneity in roll compaction/dry granulation and can it be influenced?
How relevant is ribbon homogeneity in roll compaction/dry granulation and can it be influenced?
R. Wiedey, R. Šibanc, A. Wilms, P. Kleinebudde
R. Wiedey, R. Šibanc, A. Wilms, P. Kleinebudde
research paper
research paper
A Critical Review on 3D-printed Dosage Forms
A Critical Review on 3D-printed Dosage Forms
I. El Aita, H. Ponsar, J. Quodbach
I. El Aita, H. Ponsar, J. Quodbach
research paper
research paper
